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Direktoratet for medisinske produkter (tidligere Statens legemiddelverk) har ansvaret for bytteordningen, og har konkretisert vilkårene for hva som regnes for tungtveiende medisinske grunner for et medisinbytte. Oddskvoten (OR) Resultatene for dikotome utfall (todelte utfall, for eksempel slutt vs . ikke slutt av benzodiazepiner) i denne systemat